This research assessed COVID-2019 knowledge, attitude, and behavior among college students in Guangxi Province, China. Using a descriptive research design, a cross-sectional survey was conducted online among college students from Guangxi Province, China. The electronic survey devised by the researchers includes four main segments relating to the profile of the participants, knowledge, attitude and behavior during the novel coronavirus pandemic. The study data revealed that the respondents had an adequate level of knowledge about the mode of transmission, symptoms, and prevention strategies on COVID-2019. The survey, likewise, illustrated an overall positive attitude and behavior toward these protective measures for the virus and its responses, if an infection was contracted. Also, majority of the students do not consider the virus as a stigma or hide it from medical specialists. They avoid the situation where they can get COVID-2019 and chose to seek medical treatment or isolate themselves if needed.