St. Paul University Manila kicked off its annual University Week celebration through a solemn procession on January 24 in honor of its Patron, St. Paul; the Immaculate Conception; and the Santo Niño de Pandacan.

Ending the 110th Founding Anniversary Celebration of St. Paul University Manila, a closing ceremony was held in the Fleur-de-lis Theater, in conjunction with the Blessing of Markers around the campus, led by Msgr. Gerardo O. Santos, and the launching of a coffee table book commemorating Paulinian experiences through the years. The event was attended by students, faculty, staff, and alumni, and led by the University President, Sr. Ma. Evangeline Anastacio, SPC.

In 2022, St. Paul University Manila was included in the shortlist of winners for the Blended and Presence Learning Award in the prestigious Wharton-QS Reimagine Education Awards. The project, called "The Three I’s of Flexible Learning: The Learning Model of St. Paul University Manila in COVID," was developed in response to the challenges brought about by the COVID-19 pandemic.

100%. Two “zeroes” and a single “one”: the only one that rises against nothing. PauliNARSes (a wordplay for Paulinian Nurses) have been trained to burn candles at both ends for four years. And in the Philippine Nursing Licensure Exam 2022, the Batch, Christum Serviam of St. Paul University Manila passed with flying colors—100% passing rate.

On November 19, 2022, the SPU Manila Chorale went to the Malate Church to serenade the parish patron, Our Lady of Remedies, on her feast as a part of their annual Harana Kay Maria event. This endeavor is a commitment continued by the group as the late Sr. Ma. Anunciata Sta. Ana, SPC, Dean of the College of Music and the Performing Arts, made a promise to let them perform in the parish annually for the Blessed Mother. Two years after her passing, they continue to live up to her word.